| Zymar / Zymaxid (U.S.N.L.M.) | |
|---|---|
| Dosing/ conjunctivitis | 1 drop q2hr on day 1, then bid to qid days 2 thru 7. |
| Dosing/ ulcer | In office loading dose then 2drops q15min for 2-3hr, then qhr, q3-4hr overnight (ung hs less severe cases), qhr day 2, then q2hr to significant resolution, then qid to day 14. In office loading dose then 2drops q15min for 2-3hr, then qhr, q3-4hr overnight (ung hs less severe cases), qhr day 2, then q2hr to significant resolution, then qid to day 14. |
| Chem Specs | gatifloxacin 0.3 % (Zymar) gatifloxacin 0.5%(Zymaxid) |
| Quantities | 5ml bottle (Zymar) 2.5ml (Zymaxid) |
| Cost | 102.08 generic The 5ml bottle of Zymar costs only slightly more than the 2.5ml of Zymaxid. |
| Class | fourth-generation fluoroquinolone |
| Action | Binds bacterial DNA gyrase topoisomerase II and topoisomerase IV Binds bacterial DNA gyrase topoisomerase II and topoisomerase IV |
| Activity | Active against a very broad range of gram negative and positive organisms. Click heading for details in package insert. Active against a very broad range of gram negative and positive organisms. Click heading for details in package insert. |
| Usage | Indicated for bacterial conjunctivitis, off label for corneal ulcer. |
| Enhanced gram positive activity with bulky side chains which combat resistance and enhance potency. Excellent initial kill rate. Good Pseudomonas coverage. Enhanced gram positive activity with bulky side chains which combat resistance and enhance potency. Excellent initial kill rate. Good Pseudomonas coverage. |
|
| Contraindications | Hypersensitivity to Zymar, other quinolones or any components. |
| Pediatric use | > 1 year |
| Pregnancy | No adequate and well-controlled studies in pregnant women. Administration to pregnant rats, and rabbits did not produce adverse effects at clinically relevant doses. No adequate and well-controlled studies in pregnant women. Administration to pregnant rats, and rabbits did not produce adverse effects at clinically relevant doses. |
| Zymaxid is the 0.5% reformulation of Zymar. BAK preserved. |