Tyrvaya






           Tyrvaya   (U.S.N.L.M.)
Dosing 1 spray each nostril bid.
Prime with 7 actuations before initial use. Re-prime with 1 actuation if not used for more than five (5) days.
Chem Specs 0.6 mg/mL (0.06%) varenicline solution
Quantities carton contains 2 spray bottles - 4.2ml each. (60 sprays per bottle) 0.03 mg per spray.
Cost $635.71 per carton (2 bottles)
Class selective cholinergic agonist
partial nicotinic acetylcholine receptor agonist of α4β2, α4α6β2, α3β4, and α3α5β4 receptors and a full α7 receptor agonist.
Action Activates the trigeminal parasympathetic pathway, resulting in an increased tear production.
Usage Indicated for the treatment of the signs and symptoms of dry eye disease.
11.5mm increase Schirmer's score compared to 4.75 for vehicle.
82% of study participants report sneezing reaction.
Contraindications None
Pediatric use Safety and efficacy of TYRVAYA in pediatric patients have not been established.
Pregnancy At 4864 times normal human dose rats exhibited reduced body weight.
Can be used concomitantly with artificial tears.
    N.L.M. DailyMed page for Tryvaya