| click here for details Tobradex ST (U.S.N.L.M.) | ||
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| Dosing | 1 or 2 drops q4-6 hrs, q2hr 1st 24 or 48hr if needed, taper | |
| Chem Specs | tobramycin 0.3% dexamethasone 0.05% | |
| Quantities | 2.5, 5, 10ml | |
| Cost | 234.00/5ml | |
| Class | aminoglycoside corticosteroid | |
| Action | Aminoglycosides prevent bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release. Aminoglycosides prevent bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release. |
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| Activity | Active against a wide variety of gram-negative and gram-positive bacteria includings some penicillin-resistant and gentamicin-resistant strains. Active against a wide variety of gram-negative and gram-positive bacteria includings some penicillin-resistant and gentamicin-resistant strains. |
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| Usage | Indicated for steroid-responsive inflammatory conditions where superficial bacterial infection or a risk of bacterial infection exists. Indicated for steroid-responsive inflammatory conditions where superficial bacterial infection or a risk of bacterial infection exists. |
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| Glaucoma and cataract risk with extended use. | ||
| Contraindications | Acanthamoeba, most viral, mycobacterial, and fungal disease. Hypersensitivity to this or other aminoglycosides, corticosteroids, or any components of the medication. Acanthamoeba, most viral, mycobacterial, and fungal disease. Hypersensitivity to this or other aminoglycosides, corticosteroids, or any components of the medication. |
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| Pediatric use | > 2 years | |
| Pregnancy | Category C. Ocular administration of 0.1% dexamethasone is teratogenic in rabbits. Category C. Ocular administration of 0.1% dexamethasone is teratogenic in rabbits. | |
| Addition of xanthan gum allows reduction of dexamethasone concentration to 0.05% without reducing efficacy. Addition of xanthan gum allows reduction of dexamethasone concentration to 0.05% without reducing efficacy. |
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