| Tim-Lat™ PF (U.S.N.L.M.) | |
|---|---|
| Dosing | qpm |
| Chem Specs | timolol 0.5%, latanoprost 0.005% |
| Quantities | 5ml, |
| Cost | 108.00 |
| Class |
timolol: Non-selective beta-adrenergic receptor blocker. latanoprost: Prostaglandin analog (prodrug) |
| Usage | Preservative-free, single container preparation can reduce surface toxicity and enhance compliance. Requires refrigeration. |
| Contraindications |
timolol Bronchial asthma, a history of bronchial asthma, COPD, sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, cardiogenic shock. Use caution when cerebrovascular insufficiency is suspected.
latanoprost Latanoprost hypersensitivity
|
| Side Effects |
timolol Many side effects are associated with the vascular effects of beta blocking agents. See a list here. latanoprost Generally less hyperemia, less pigmentation of iris, and lids than Lumigan. Possible cystoid macular edema in pseudophakes and/or aphakes. May exacerbated iritis/uveitis. Possible reactivation of herpes simplex and zoster. Dry eye-like surface inflammation observed in mice.1 Avoid with inflammatory glaucomas and surface eye disease. |
| Pediatric use | Safety and effectiveness in pediatric patients have not been established. Latanoprost has been used in children as young as 5 yrs without notable problems.2 |
| Pregnancy | Category C Embryofetal lethality shown in rats and rabbits at clinically relevant doses. |
| Bottle with one way valve requires Refrigeration. Individual drugs are FDA approved but the combination is not. |