| Tim-Brim-Dor-Lat™PF (U.S.N.L.M.) | |
|---|---|
| Dosing | q.p.m. This is the PM arm of the "Triple/Quad, AM - PM pairing". It is intended for use in unison with the triple "AM combination"1. |
| Chem Specs | timolol 0.5%, brimonidine 0.15%, dorzolamide 2.0%, latanoprost 0.005% |
| Quantities | 5ml, |
| Cost | 152.00 |
| Class | timolol: Non-selective beta-adrenergic receptor blocker. brimonidine: Relatively selective alpha-2 agonist. dorzolamide: Carbonic anhydrase inhibitor latanoprost: Prostaglandin analog (prodrug) |
| Usage | The preservative-free, single container preparation can reduce surface toxicity and enhance compliance. |
| Contraindications |
timolol Bronchial asthma, a history of bronchial asthma, COPD, sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, cardiogenic shock. Numerous additional cautions listed here.
brimonidine neonates and infants (under the age of 2 years) Vascular insufficiency cautions listed here.
dorzolamide Sulfonamide hypersensitivity.
latanoprost Latanoprost hypersensitivity |
| Pediatric use | Safety and effectiveness in pediatric patients have not been established. |
| Pregnancy | Category C Embryofetal lethality shown in rats and rabbits at clinically relevant doses. |
| 1. The "AM combination" Tim-Brim-Dor™ is similar but lacks latanaprost (daily dosing). | |
| Bottle with one way valve requires refrigeration. Individual drugs are FDA approved but the combination is not. |