| Pred-G (U.S.N.L.M.) | ||
|---|---|---|
| Dosing | Up to 1 drop every hr 1st 24 -48 hr. Then 1 drop 2-4x daily. | |
| Chem Specs | gentamicin sulfate 0.3% and prednisolone acetate 1% | |
| Quantities | 5ml | |
| Cost | 195.00/5ml | |
| Class | aminoglycoside, corticosteroid | |
| Action | Aminoglycosides prevent bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release. Aminoglycosides prevent bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release. |
|
| Activity | Active against a variety of aerobic bacteria including Pseudomonas aeruginosa, Haemophilus influenzae, Staph aureus, and Serratia marcescens. Active against a variety of aerobic bacteria including Pseudomonas aeruginosa, Haemophilus influenzae, Staph aureus, and Serratia marcescens. |
|
| Usage | Indicated for steroid-responsive inflammatory conditions where superficial bacterial infection or a risk of bacterial infection exists. Indicated for steroid-responsive inflammatory conditions where superficial bacterial infection or a risk of bacterial infection exists. |
|
| Glaucoma and cataract risk with extended use. | ||
| Contraindications | Most viral, mycobacterial, and fungal disease. Hypersensitivity to this or other aminoglycosides, corticosteroids, or any components of the medication. Most viral, mycobacterial, and fungal disease. Hypersensitivity to this or other amino- glycosides, corticosteroids, or any components of the medication. |
|
| Pediatric use | Safety and effectiveness not established in pediatric patients. | |
| Pregnancy | While systemic use during pregnancy can cause fetal hearing loss, the PDR states that limited ophthalmic use is unlikely to cause harm. Fetal harm has been shown in rats at 500x the ophthalmic human dose. While systemic use during pregnancy can cause fetal hearing loss, the PDR states that limited ophthalmic use is unlikely to cause harm. Fetal harm has been shown in rats at 500x the ophthalmic human dose. |
|
| Exercise caution with severe or unresponsive keratitis as steroids will exacerbate many nonbacterial infections. |
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