Natacyn (U.S.N.L.M.)
Dosing/ keratitis	1 drop every hour while awake, every 2 hours at night x 3-4 days, then 1 drop 6-8 times/day. Continue 14 to 21 days. For blepharitis and conjunctivitis reduce initial dose to 4 to 6 drops per day.
Chem Specs	natamycin 5%
Quantities	15ml glass bottle with dropper
Cost	479.00
Class	Polyene amphoteric macrolide antifungal
Action	Alters fungal cell membrane permeability by binding with membrane sterols.
Activity	Active against a variety of yeast and filamentous fungi including Candida, Aspergillus, Cephalosporium, and Fusarium. Active against a variety of yeast and filamentous fungi including Candida, Aspergillus, Cephalosporium, and Fusarium.
Usage	Indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis. Indicated for the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.
Contraindications	Hypersensitivity to natamycin any Natacyn components.
Pediatric use	Safety and effectiveness in pediatric patients have not been established.
Pregnancy	Neither human nor animal reproduction studies have not been conducted with natamycin. Natamyin is a common food addative (in the U.S.).
Drug is viscous, irritating, and has poor penetration . Alternatives include 1% voriconazole drops prepared from powder and orals voriconazole (Vfend)¹ and fluconazole (Diflucan) or injected Amphotericin B (Fungizone, Bristol-Myers Squibb). Drug is viscous, irritating, and has poor penetration . Alternatives include 1% voriconazole drops prepared from powder and orals voriconazole (Vfend)¹ and fluconazole (Diflucan) or injected Amphotericin B (Fungizone, Bristol-Myers Squibb).

1. Rose-Nussbaumer JR, Am Acad Oph, Chicago, Oct. 14-18, 2016; Fusarium subgroup may show better response with supplementation.

N.L.M. DailyMed page for Natacyn PDR page for Natacyn