| Maxitrol Ointment Ointment (U.S.N.L.M.) | ||
|---|---|---|
| Dosing | 1/2" tid or qid. Taper | |
| Chem Specs | neomycin 0.35%, polymyxin B, dexamethasone 0.1% | |
| Quantities | 3.5 gm tube | |
| Cost | 29.22 generic | |
| Class | aminoglycoside, cationic detergent, corticosteroid | |
| Action | Aminoglycosides inhibit bacterial protein synthesis so are active against gram-positive species. Polymyxins bind to bacterial cell membrane increasing permeability so are active against gram-negative species. Corticosteroids inhibit arachidonic acid release . Aminoglycosides inhibit bacterial protein synthesis so are active against gram-positive species. Polymyxins bind to bacterial cell membrane increasing permeability so are active against gram-negative species. Corticosteroids inhibit arachidonic acid release . |
|
| Activity | Active against Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. Active against Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. |
|
| Usage | Indicated for ocular surface and palpebral conjunctival inflammation where a risk of bacterial infection exists. Indicated for ocular surface and palpebral conjunctival inflammation where a risk of bacterial infection exists. |
|
| Inadequate coverage against: Serratia marcesens and streptococci, including Streptococcus pneumoniae. Hypersensitivity to neomycin is common. Glaucoma risk with extended use. Inadequate coverage against: Serratia marcesens and streptococci, including Streptococcus pneumoniae. Hypersensitivity to neomycin is common. Glaucoma risk with extended use. |
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| Contraindications | Acanthamoeba, most viral, mycobacterial, and fungal disease. Hypersensitivity to any component.1. |
|
| Pediatric use | > 2 years | |
| Pregnancy | Category C. Dexamethasone is teratogenic in animals following topical ophthalmic application in "multiples of the therapeutic dose". Category C. Dexamethasone is teratogenic in animals following topical ophthalmic application in "multiples of the therapeutic dose". |
|
| Commonly used for staph blepharitis when cost is a concern. | ||
| Generic: Neo Poly Dex Ointment, NPD Ophthalmic Ointment | ||
| 1. Neomycin sensitivity is common but it is not considered a classical sulfonamide sensitivity. Shah, Moshirfar, Hoopes. Ophthalmology and Therapy, December 2018, Volume 7, Issue 2, pp 211–215. |
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