| Maxitrol (U.S.N.L.M.) | ||||
|---|---|---|---|---|
| Dosing | 1 or 2 drops qhr severe disease, 4 - 6x/dy for mild disease. Taper | |||
| Chem Specs | neomycin 0.35% polymyxin B 10,000u dexamethasone 0.1% | |||
| Quantities | 5 mL | |||
| Cost | 21.27 generic | |||
| Class | aminoglycoside, cationic detergent, corticosteroid | |||
| Action | Aminoglycosides inhibit bacterial protein synthesis. Polymyxins bind to bacterial cell membrane increasing permeability. Corticosteroids inhibit arachidonic acid release . Aminoglycosides inhibit bacterial protein synthesis. Polymyxins bind to bacterial cell membrane increasing permeability. Corticosteroids inhibit arachidonic acid release . |
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| Activity | Active against Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa Active against Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa |
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| Usage | Indicated for ocular surface inflammation where superficial bacterial infection or a risk of bacterial infection exists. Indicated for ocular surface inflammation where superficial bacterial infection or a risk of bacterial infection exists. |
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| Inadequate coverage against: Serratia marcesens and streptococci, including Streptococcus pneumoniae. Hypersensitivity to neomycin is common. Glaucoma risk with extended use. Inadequate coverage against: Serratia marcesens and streptococci, including Streptococcus pneumoniae. Hypersensitivity to neomycin is common. Glaucoma risk with extended use. |
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| Contraindications | Acanthamoeba, most viral, mycobacterial, and fungal disease. Hypersensitivity to any component.1. |
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| Pediatric use | > 2 years | |||
| Pregnancy | Category C. Dexamethasone is teratogenic in animals following topical ophthalmic application in "multiples of the therapeutic dose". Dexamethasone is teratogenic in animals following topical ophthalmic application in "multiples of the therapeutic dose". |
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| generics |
Neo Poly Dex (B&L) ,
Falcon (Alcon) ,
B&L ,
AK-Trol, Dexacidin, Dexasporin
| 1. Neomycin sensitivity is common but it is not considered a classical sulfonamide sensitivity. |
Shah, Moshirfar, Hoopes. Ophthalmology and Therapy, December 2018, Volume 7, Issue 2, pp 211–215. | ||